Medical Laboratory Scientist (MLS) ASCP Exam 2025 – 400 Free Practice Questions to Pass the Exam

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What is the primary cell type that binds most effectively to IgE antibodies?

Monocytes

B lymphocytes

Basophiles

The primary cell type that binds most effectively to IgE antibodies is basophiles. Basophils have specific receptors known as high-affinity IgE receptors (FcεRI) on their surface. When IgE antibodies bind to allergens, basophils become activated, leading to the release of histamine and other inflammatory mediators. This response plays a crucial role in allergic reactions and the immune response to parasites.

While other cell types, such as eosinophils, also play a role in allergic responses and bind to IgE, basophils are the most effective in this specific binding due to their specialized receptors. Monocytes and B lymphocytes do not bind IgE in the same manner; monocytes are more involved in phagocytosis, and B lymphocytes are responsible for producing antibodies rather than directly binding IgE as part of an allergic response.

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Eosinophils

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