Medical Laboratory Scientist (MLS) ASCP Exam 2025 – 400 Free Practice Questions to Pass the Exam

Alpha thalassemia intermedia is characterized by varying levels of anemia and splenomegaly, which are key clinical features of this condition. Anemia occurs due to a reduced production of normal hemoglobin, leading to the presence of fewer healthy red blood cells in circulation. This can cause a range of symptoms, such as fatigue and weakness, commonly associated with anemia.

Splenomegaly, or enlargement of the spleen, often occurs as a consequence of the excessive breakdown of damaged or abnormal red blood cells. The spleen plays a crucial role in filtering blood and removing these ineffective cells, leading to its enlargement due to overactivity.

The other options provided do not accurately represent the common characteristics of alpha thalassemia intermedia. Hemophilia is a bleeding disorder and is not related to thalassemia, jaundice and leukopenia are not primary features of this condition, and polycythemia implies an increase in red blood cells, which contrasts with the anemia seen in alpha thalassemia intermedia. Therefore, the association of anemia and splenomegaly is correct as it directly reflects the pathophysiological mechanisms at play in this form of thalassemia.