Medical Laboratory Scientist (MLS) ASCP Exam 2025 – 400 Free Practice Questions to Pass the Exam

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Which one of the following is a major consequence of treating a neonate with blood relative donor units?

Increased risk of transfusion reactions

Development of Graft-Versus-Host Disease (GVHD)

Treating a neonate with blood relative donor units significantly increases the risk of developing Graft-Versus-Host Disease (GVHD). This condition occurs when transfused immune cells recognize the recipient's tissues as foreign and mount an immune response against them. Neonates are particularly vulnerable to this complication due to their immature immune systems. When blood is donated by a relative, the donor's immune cells may still function and attack the neonate's cells, leading to GVHD.

In neonatal care, careful consideration is given to blood transfusions, and measures are often taken to minimize the risk of GVHD, such as using irradiated blood products for at-risk patients. The connection between the relationship of the donor and the recipient, especially in the context of a neonate's developing immune system, highlights the importance of donor selection to prevent complications associated with transfusion.

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Higher likelihood of iron overload

Faster red cell turnover

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